ortho -Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization

Highly selective metal mediated ortho-alkylation of phenol. First platinum containing organometallic chromane analogues.

We were able, for the first time, to synthesize and characterize Pt derivatives with a structural shape similar to vitamin E, having a metalla-chromane core. The formation reaction mechanism includes an unexpected highly selective ortho aromatic electrophilic substitution on phenol, operated by [PtCl(eta(1)-C(2)H(4)OR)(N-N)], R = Me or Ph, and a final cyclization step. The X-ray structure of on...

highly selective vagotomy

چکیده ندارد.

Highly Lipophilic Camptothecin Intermediates and Prodrugs and Methods of Preparation Thereof

Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereof.

A highly efficient and scalable synthesis of potent lipid peroxidation inhibitor pyrrolostatin is reported (4 steps, 48%). In addition to the synthesis of the natural product, strategies for the preparation of analogues differing in the three structural subunits, the polar head group, the N-substituent and the lipophilic tail are described.

Camptothecin Intermediates and Prodrugs and Methods of Preparation Thereof